Dr. Ye Fu
Joining Plaisance in 2020, Ye Fu specializes in exploring innovative ideas and developing scientific strategies to create breakthrough companies. Ye has broad multidisciplinary training at the interface of Biology, Chemistry, and Biophysics.
Prior to joining Plaisance, Ye was a postdoctoral researcher in the lab of Xiaowei Zhuang at Harvard University, where he used quantitative imaging and super-resolution imaging to study the function of RNA m6A-binding proteins in regulating the phase-separation of stress granules in mammalian cells.
Ye completed his graduate work in the lab of Chuan He at the University of Chicago, where he pioneered the work on RNA modifications and co-discovered the function of FTO as the first RNA m6A demethylase in 2011—a landmark in the field of epitranscriptomics. In addition, he developed high-throughput sequencing methods to map the genome-wide distribution of several base modifications—including 6mA and 5hmC in the eukaryotic genomes—and revealed their functions in regulating gene expression. His work in DNA and RNA modifications have greatly impacted therapeutics development and diagnosis. Additionally, he performed undergraduate research in developing Gold and Palladium-catalyzed C-H bond functionalization reactions and applications in the total synthesis of small molecules.
Ye holds a Ph.D. and M.S. in Chemistry from the University of Chicago and a B.S. in Chemistry from Peking University in China. He has published more than 25 peer-reviewed publications, including first author articles in the journal Cell, Nature Chemical Biology, as well as Nature Reviews Genetics. His work has been cited more than 15,000 times.